Change the views and current treatment for DVT. Taking charge of future studies in the field of blood coagulation. With the advancements in third generation blood thinning products, we as a society have became complacent in looking for a cure. The cure will hopefully be discovered from within institutions who study genetics. Not only will genetic research find the the answers to blood coagulation issues, but hopefully medical discoveries in other major diseases.
History/Origin
Bradley Hollar was 26 years old, married, with a 11 month old daughter working for a major pharmaceutical company in the Midwest when his life tragically ended unexpectedly. On February 27th, 2013, Bradley passed away instantly in his home. Weeks later the family was informed that his cause of death was that he had developed a blood clot that settled in his lungs. Upon autopsy results and pharmacology testing, it was discovered that Bradley suffered from a rare blood clotting disorder. The disorder is called Factor Five Leiden Mutation which is a genetic condition. In response to these finding, the family was advised that this genetic mutation is passed on through generations. Immediate testing found that Bradley’s only daughter as well as other family members, possesses the same genetic signature. After reviewing previous deaths of family members’, it was discovered that this genetic mutation may well have been the cause of other deaths. The only way that this discovery was made, is the direct result of Bradley’s death. His life although cut short, was not in vain. Within the first two years of his association with the pharmaceutical company, he was able to advance his career to the top of the sales field. Most long term or seasoned sales associates never obtain the prestigious honor of being at the top of the team and earning the President Club jacket. Within his first two years, Bradley obtained that honor. He was the youngest person in his organization to achieve that honor. Bradley possessed an extraordinary personality that became his trademark in making a difference with anyone he came into contact with. Although his family and career guided him, his faith was always at the forefront of Bradley’s decisions on his very short journey of life. He had accomplished achievements that were far beyond his time. His death may have been the very factor that has and will continue to save the lives of not only his family but of countless others who are affected by this rare, genetic condition. This fact alone is one of many reasons why the organization is eager to ignite the industry in testing, education to benefit others in the future. Factor V Leiden Factor V Leiden thrombophilia is an inherited disorder of blood clotting. Factor V Leiden is the name of a specific gene mutation that results in thrombophilia, which is an increased tendency to form abnormal blood clots that can block blood vessels. People with factor V Leiden thrombophilia have a higher than average risk of developing a type of blood clot called a deep venous thrombosis (DVT). DVTs occur most often in the legs, although they can also occur in other parts of the body, including the brain, eyes, liver, and kidneys. Factor V Leiden thrombophilia also increases the risk that clots will break away from their original site and travel through the bloodstream. These clots can lodge in the lungs, where they are known as pulmonary emboli. Although factor V Leiden thrombophilia increases the risk of blood clots, only about 10 percent of individuals with the factor V Leiden mutation ever develop abnormal clots. The factor V Leiden mutation is associated with a slightly increased risk of pregnancy loss (miscarriage). Women with this mutation are two to three times more likely to have multiple (recurrent) miscarriages or a pregnancy loss during the second or third trimester. Some research suggests that the factor V Leiden mutation may also increase the risk of other complications during pregnancy, including pregnancy-induced high blood pressure (preeclampsia), slow fetal growth, and early separation of the placenta from the uterine wall (placental abruption). However, the association between the factor V Leiden mutation and these complications has not been confirmed. Most women with factor V Leiden thrombophilia have normal pregnancies.